The only mention I've seen on this (very small) forum is an older version run through Wine on Linux.
http://secretsofgrindea.com/forum/index.php?threads/linux-try.130/#post-5734
Whether it's relevant for newer versions, I haven't a clue. Nor do I know if Linux and Mac's Wine differs. I also recall failing to get the game to function on Linux, so there's that. I have a feeling Linux/Mac help is going to be in short supply until the game gets more exposure.
There is also the issue of there being, I think, no frontline version for the non-steam version; so a virtual machine might still be preferable if you can get it to run decently.